All articles

Acute Myeloid Leukemia Treatment

Guide to antimicrobial prophylaxis in hematologic malignancies, outlining risk-based indications during neutropenia, bacterial/fungal/viral prophylaxis options, PJP prevention criteria, key medication contraindications, and IVIG use after CAR-T or bispecific therapies.

Overview of CAR-T therapy, covering lymphodepleting chemotherapy, major FDA-approved products by disease, use of prophylactic dexamethasone, expected toxicities (CRS/ICANS and cytopenias), and standard antimicrobial prophylaxis in the peri-CAR-T period.

Overview of CRS and ICANS associated with CAR-T and bispecific therapies, summarizing risk timing, diagnostic workup, grading, and stepwise management using supportive care, tocilizumab, corticosteroids, and ICU escalation per ASCO guidelines.

Overview of differentiation syndrome, most commonly seen during induction therapy for APL with ATRA and/or ATO, outlining typical timing, key clinical features, severity grading, and prompt management with IV dexamethasone and temporary therapy interruption when severe.

Overview of aggressive lymphomas seen in the inpatient setting, covering key subtypes, staging and risk stratification (IPI), double-/triple-hit biology, and frontline, salvage, and CNS-directed treatment regimens, including CAR-T and bispecific immunotherapies.

Overview of multiple myeloma diagnosis and management, covering key labs, SLiM-CRAB criteria, risk stratification, frontline and relapsed therapies, transplant strategies, and emerging immunotherapies including bispecifics and CAR-T.

Clinical guide to neutropenic fever management, covering definitions, overnight response, empiric antibiotics, indications for antifungal escalation, evaluation of common infectious sources, and safe supportive care during neutropenia.

Checklist for evaluating a new leukemia diagnosis, highlighting red-flag symptoms, immediate actions, essential diagnostic labs, tumor lysis and infectious workup, early supportive care, and urgent cytoreduction steps for leukostasis or suspected APL.

Reference for transfusion thresholds in hematologic malignancies, including red blood cell and platelet cutoffs, mandatory use of irradiated blood products, and special ordering considerations to avoid pathogen-reduced platelets when transfusion response is inadequate.

Overview of tumor lysis syndrome, including risk stratification, Cairo–Bishop diagnostic criteria, prophylaxis strategies, fluid and rasburicase use, electrolyte management, and indications for escalation to hemodialysis.

Specific situations that require escalation to a fellow.