Complications & Syndromes

Overview of CRS and ICANS associated with CAR-T and bispecific therapies, summarizing risk timing, diagnostic workup, grading, and stepwise management using supportive care, tocilizumab, corticosteroids, and ICU escalation per ASCO guidelines.

Overview of differentiation syndrome, most commonly seen during induction therapy for APL with ATRA and/or ATO, outlining typical timing, key clinical features, severity grading, and prompt management with IV dexamethasone and temporary therapy interruption when severe.

Overview of tumor lysis syndrome, including risk stratification, Cairo–Bishop diagnostic criteria, prophylaxis strategies, fluid and rasburicase use, electrolyte management, and indications for escalation to hemodialysis.